Whereas very low-count MBL seldom progresses to CLL, significant-count MBL progresses to CLL requiring therapy in a rate of 1% to 2% per annum. Substantial-depend MBL is distinguished from Rai 0 CLL based upon whether the B-mobile count is higher than or beneath five × 109/L. Though people today with both high-depend MBL and CLL Rai stage 0 are at